Inverse‐Electron‐Demand Diels–Alder Reactions of 2‐Pyrones: Bridged Lactones and Beyond
نویسندگان
چکیده
Inverse-electron-demand Diels–Alder (IEDDA) reactions of electron-poor 2-pyrones as electrophilic dienes have been extensively studied in the past fifty years. These provide an efficient access to bridged bicyclic lactones and their derivatives, such densely functionalized 1,3-cyclohexadienes after CO2 extrusion polysubstituted aromatic compounds through elimination. This reaction has used for synthesis many biologically active natural products drug candidates. In this review, developments these IEDDA including non-catalytic, Lewis acid-catalyzed organocatalytic reactions, applications total are discussed detail.
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ژورنال
عنوان ژورنال: Chemistry: A European Journal
سال: 2021
ISSN: ['0947-6539', '1521-3765']
DOI: https://doi.org/10.1002/chem.202003980